This is a prospective, randomized controlled pilot clinical trial evaluating the efficacy of a human placental-derived amnion chorion membrane (Biotivityâ„¢ A/C Plus Membrane) versus a conventional collagen membrane in alveolar ridge preservation (ARP) following atraumatic extraction of single posterior teeth. A total of 12 subjects will be enrolled at the University of Maryland School of Dentistry. The study aims to assess both soft tissue wound healing and hard/soft tissue dimensional changes over a 5-month period prior to dental implant placement.
Throughout the approximately 6-month study duration, participants will undergo oral exams, x-rays, surgical procedures, and follow-up visits. All participants will undergo routine tooth extraction, bone graft material and barrier placement, and dental implant placement.
Participation in the study is voluntary, and the alternative is to continue routine dental care. Risks include minor discomfort from procedures such as tooth extraction and implant placement. The major benefit of participation in the study is the preservation of jaw dimensions following extraction, which will simplify the placement of a dental implant.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Provision of informed consent
✓. At least 18 years old
✓. In need of one posterior tooth (premolar or molar), excluding third molars, planned for extraction and replacement with a dental implant
✓. Type I or II extraction socket/ ridge identified at the time of enrolment with cone-beam CT scan
✓. At least one retained natural tooth adjacent to the study site
Exclusion criteria
✕. Insufficient interocclusal or interdental space to allow for an implant- supported prosthesis
✕. Previous interventions performed involving soft and/or bone grafting in the study site
✕. Active caries
✕. Uncontrolled periodontal disease present
✕. Evidence of active periapical, radicular, or endodontic lesions on teeth adjacent to study site
What they're measuring
1
Soft Tissue Wound Healing Score Using Wound Healing Indices
Timeframe: Over the course of the study (From the time of study enrollment Alveolar Ridge Preservation [Visit 2] to 5-month dental implant placement [Visit6].