RecruitingNot Applicable

A Study of Herbal Supplements in Cancer Survivors With Constipation

United States70 participantsStarted 2025-07-15

Plain-language summary

The purpose of this study is to find out whether MZRW is an effective treatment for constipation in cancer survivors. The researchers will compare MZRW with placebo, a pill that looks like MZRW and is given in the same way, but contains no medication. The researchers will also study the effect MZRW has on the gut microbiome. The gut microbiome is a diverse community of microorganisms living in the digestive system, essential for digestion and immune function.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Must include two or more of the following:\*\*
✓. Straining during more than ¼ (25%) of defecations
✓. Lumpy or hard stools (Bristol Stool Form Scale 1-2) more than ¼ (25%) of defecations
✓. Sensation of incomplete evacuation more than ¼ (25%) of defecations
✓. Sensation of anorectal obstruction/blockage more than ¼ (25%) of defecations
✓. Fewer than three SBM per week
✓. Manual maneuvers to facilitate more than ¼ (25%) of defecations (e.g., digital evacuation, support of the pelvic floor)

What they're measuring

Difference of spontaneous bowel movements (SBMs) from baseline to week 2

Timeframe: 2 weeks

Trial details

NCT IDNCT07091084

SponsorMemorial Sloan Kettering Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-07-15

Contact for this trial

Jun Mao, MD, MSCE

646-608-8552 maoj@mskcc.org

View on ClinicalTrials.gov More Constipation trials