By InvitationPhase 1

PRF vs. Graftless Sinus Lift With Implant Placement

Saudi Arabia8 participantsStarted 2025-02-01

Plain-language summary

The goal of this clinical trial is to evaluate the effectiveness of sinus floor elevation using platelet-rich fibrin (PRF) compared to a graftless approach in adult patients with atrophic posterior maxilla (residual bone height 5-7 mm) requiring dental implant rehabilitation. The main questions it aims to answer are: Does PRF enhance bone height gain more effectively than graftless sinus elevation? Does PRF improve implant stability and reduce marginal bone loss compared to the graftless approach? Researchers will compare the outcomes of PRF-grafted implants versus non-grafted implants to see if PRF improves radiographic and clinical results in single-stage implant placement. Participants will: Undergo internal sinus lift via crestal drilling approach Be randomly assigned to one of two groups: Group I: sinus lift without graft material Group II: sinus lift with PRF as the sole grafting material Receive simultaneous dental implant placement during the sinus lift Be monitored through clinical exams and radiographic imaging over 6 months postoperatively

Who can participate

Age range25 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 25 to 65 years * Patients with one or more missing posterior maxillary teeth * Residual alveolar bone height between 5 mm and 7 mm, confirmed by CBCT * Good oral hygiene and motivation for implant therapy * Adequate inter-arch space for prosthetic rehabilitation * Absence of maxillary sinus pathology on radiographic assessment * Patients willing to undergo single-stage implant placement with sinus lift * Signed informed consent Exclusion Criteria: * Systemic diseases or medical conditions affecting bone metabolism or wound healing (e.g., uncontrolled diabetes, osteoporosis, immunocompromised status) * History of radiation therapy in the head and neck region * Use of medications influencing bone turnover (e.g., bisphosphonates, corticosteroids) * Active periodontal disease or poor oral hygiene * Smoking or tobacco use * Parafunctional habits such as bruxism or clenching * Pregnancy or breastfeeding * Known bleeding disorders or abnormal coagulation profiles * Presence of maxillary sinus infection or pathology * Inability to attend follow-up visits or comply with study protocol

What they're measuring

Radiographic Bone Height Gain

Timeframe: Baseline and 6 months postoperatively

Trial details

NCT IDNCT07090694

SponsorDar Al Uloom University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08