The Effects of Age on Muscle Endurance During Resistance Exercise With and Without Blood Flow Res… (NCT07090603) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Effects of Age on Muscle Endurance During Resistance Exercise With and Without Blood Flow Restriction
Canada20 participantsStarted 2025-09
Plain-language summary
The purpose of this study is to learn how aging affects muscle endurance during resistance exercise, and how oxygen delivery to the muscles plays a role in these changes. To answer this question, we are comparing how many repetitions of a leg exercise (knee extensions) younger and older adults can do at different exercise intensities. We will also look at how the muscles use oxygen during these exercises.
Participants will take part in 12 different exercise sessions. In each session, they will perform as many knee extensions as possible using different amounts of weight-consisting of 20%, 30%, 40%, 50%, 60% and 70% of the maximum weight they can lift one time. Each weight will be tested both with and without a cuff on the leg that temporarily reduces blood flow to the muscle.
Who can participate
Age range
19 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Able to understand and communicate in English
* 19-35 years of age
* 65 years of age or older
* All "No" answers on the CSEP Get Active questionnaire or doctors' approval to participate
Exclusion Criteria:
* BMI lower than 18 or greater than 32
* Current use of cigarettes or other nicotine devices
* Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
* Any medical condition impacting the ability to participate in maximal exercise
* Type one or type two diabetes
* Diagnosis of cancer or undergoing cancer treatment in the past 12 months
* Taking blood-thinning medication or the presence of a bleeding disorder
* Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines)
* Lowest calculated exercise testing load is less than the lightest weight able to be provided by the lab gymnasium equipment
* In the past six months, completing more than 300 minutes of moderate physical activity or 150 minutes of vigorous physical activity per week
* In the past six months, completing less than 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Maximum repetitions performed during knee extension exercise
Timeframe: From enrollment to the end of the final study visit (~4 weeks)