Multiomics Profiling of CSF in Cardiac Arrest Survivors (NCT07090577) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Multiomics Profiling of CSF in Cardiac Arrest Survivors
South Korea15 participantsStarted 2025-07-22
Plain-language summary
The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples. The main question it aims to answer is:
A. The main question it aims to answer is: What are the dynamic molecular changes in serum and CSF that reflect the pathophysiological mechanisms of secondary brain injury after cardiac arrest? B. What are the differences in serum and CSF multiomic signatures between varying severities of cardiac arrest, and how are these differences associated with the underlying pathophysiological mechanisms of secondary brain injury?
Serum and CSF samples that have already been prospectively collected from participants and stored in the BioBank will be used for this analysis.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years old
* Out-of-hospital cardiac arrest (OHCA)
* Patients who have received post-resuscitation care including temperature control due to unconsciousness (Glasgow Coma Score \< 8) after sustained ROSC.
* Patients who consented to the placement of lumbar catheter for storing cerebrospinal fluid and blood samples in a human biobank.
Exclusion Criteria:
* Patients diagnosed with a central nervous system-related disease before cardiac arrest
* Patients who have undergone extracorporeal circulatory membrane oxygenation therapy
* Patients who died within 24 hours from post-resuscitation care
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this study is focused on collecting and analyzing cerebrospinal fluid from cardiac arrest survivors, what would that procedure actually involve for me, and what are the risks of having a lumbar puncture or similar CSF collection done during my recovery?
2This trial is listed as 'active, not recruiting' — does that mean enrollment is already closed, and if so, are there similar studies looking at brain injury after cardiac arrest that I might still be eligible for?
3The study is measuring neurological outcomes using something called multiomics profiling of CSF — can you explain what that means in plain terms, and whether participating would give me or my care team any direct information about my own brain recovery?
4Since this appears to be an observational or profiling study rather than a treatment trial, would taking part in it affect my standard care after cardiac arrest in any way, or would my treatment plan stay exactly the same?
5Given that I'm dealing with hypoxic-ischemic brain injury after cardiac arrest, are there any treatment-focused trials or standard rehabilitation programs you'd recommend I consider alongside or instead of a research study like this one?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Neurological outcome
Timeframe: after 6 months from return of spontaneous circulation