Not Yet RecruitingNot Applicable

Nephroprotection Following Perinatal Asphyxia: Randomized Controlled Trial

30 participantsStarted 2025-07-30

Plain-language summary

The aim of this study is to determine the value of Pentoxifylline for nephroprotection in these neonates with perinatal asphyxia, using cystatin C, regional oxygenation measured near infrared spectroscopy and renal Doppler sonography.

Who can participate

Age range1 Hour – 5 Days

SexALL

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Inclusion criteria

✓. Evidence of perinatal hypoxia, as indicated by at least one of the following:
✓. Apgar score of less than or equal to 5 at 10 minutes.
✓. ongoing resuscitation at 10 minutes.
✓. pH less than 7.14 or a base deficit worse than or equal to minus 12 mmol/L on cord/arterial/venous/capillary blood gas obtained within 60 minutes of birth.
✓. Evidence of moderate to severe encephalopathy using Sarnat staging score.(14)
✓. Greater than or equal to 35 weeks gestational age.
✓. Birth weight greater than or equal to 1800 g.

What they're measuring

Renal function

Timeframe: daily in the first 3 days of life.

Trial details

NCT IDNCT07088328

SponsorAlexandria University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-30

Contact for this trial

Marwa M Farag, PhD

01288681788 d.marwa.farag@gmail.com

View on ClinicalTrials.gov More Hypoxic-Ischemic Encephalopathy trials