Not Yet RecruitingNot Applicable

The Clinical Study of Bone-patellar Tendon-bone and Quasi-anatomical Meniscus Allograft Transplantation Technique

200 participantsStarted 2025-08-01

Plain-language summary

This clinical study investigates the outcomes of bone-patellar tendon-bone and quasi-anatomical meniscus allograft transplantation techniques in patients requiring joint reconstruction. The study aims to assess the safety, efficacy, and functional improvements following these transplant procedures, utilizing donor tissues to restore joint function and alleviate pain in individuals with severe knee damage. Participants will undergo the transplantation procedure and be monitored for post-operative recovery, complications, and long-term outcomes, including joint stability and mobility. The study seeks to provide valuable insights into the effectiveness of these advanced surgical techniques for knee joint repair.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 18-50 years * Clinical diagnosis of symptomatic meniscal deficiency and anterior cruciate ligament injury (complete rupture or severe damage) * Failure of conservative treatment (e.g., physical therapy, analgesia) for ≥6 months * Stable knee joint (no ligamentous instability confirmed via clinical exam and MRI) * Willingness to comply with postoperative rehabilitation and follow-up evaluations Exclusion Criteria: * Severe tibiofemoral osteoarthritis (Kellgren-Lawrence grade ≥3) * History of prior knee infection or septic arthritis * Inflammatory arthritis (e.g., rheumatoid arthritis, gout) * BMI ≥35 kg/m² * Pregnancy or planning pregnancy during the study period * Concurrent full-thickness chondral defects (Outerbridge grade III-IV) in the affected compartment * Inability to undergo MRI (e.g., claustrophobia, metallic implants)

What they're measuring

Incidence of Postoperative Complications Unit of Measure

Timeframe: 2 years

Functional Improvement in Knee Joint Unit of Measure-Knee Society Score (KSS)

Timeframe: 2 years

Functional Improvement in Knee Joint Unit of Measure-Lysholm Knee Score

Timeframe: 2 years

Trial details

NCT IDNCT07088094

SponsorBeijing Tsinghua Chang Gung Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-05-31

View on ClinicalTrials.gov More Meniscal Tears trials

Plain-language summary

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.