RecruitingEarly Phase 1

Cocaine and Pentoxifylline (BED IN 47)

United States30 participantsStarted 2025-11-10

Plain-language summary

This will be a human laboratory study evaluating the influence of pentoxifylline treatment on the effects of cocaine. Supported by and included in the Helping to End Addiction Long-term® (HEAL) Initiative.

Who can participate

Age range18 Years – 55 Years

SexALL

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Inclusion criteria

✓. able to speak/read English,
✓. not seeking treatment for drug use at the time of the study,
✓. female or male between the ages of 18 and 55 years,
✓. recent smoked or intravenous cocaine use verified by benzoylecgonine positive urine, as well as fulfillment of DSM-5 diagnostic criteria for CUD,
✓. judged to be medically and psychiatrically healthy by study physicians other than the diagnosis for CUD at the time of screening,
✓. ECG, read by a cardiologist, within normal limits,
✓. females using an effective form of birth control and not pregnant or breastfeeding and 8) no known contraindications or allergies to pentoxifylline.

Exclusion criteria

✕. unable to speak/read English,
✕. seeking treatment for drug use,
✕. under 18 years or over 55 years,
✕. no recent smoked or intravenous cocaine use as indicated by benzoylecgonine negative urine and no DSM-5 diagnosis of CUD,
✕. judged to be medically or psychiatrically unhealthy by study physicians at the time of screening,
✕. ECG, read by a cardiologist, outside normal limits,
✕. females not using an effective form of birth control or pregnant or breastfeeding,
✕. contraindications or allergies to pentoxifylline, and

What they're measuring

Reinforcing Effects of Cocaine

Timeframe: 9 times over approximately 1 month inpatient admission

Trial details

NCT IDNCT07086794

SponsorWilliam Stoops

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-02-28

Contact for this trial

William W Stoops, PhD

859-257-5388 william.stoops@uky.edu

View on ClinicalTrials.gov More Cocaine Use Disorder trials