Effect of Cyanoacrylate Tissue Adhesive Versus Collagen Sponge on Palatal Donor Site Healing (NCT07086482) | Clinical Trial Compass
RecruitingEarly Phase 1
Effect of Cyanoacrylate Tissue Adhesive Versus Collagen Sponge on Palatal Donor Site Healing
Lebanon22 participantsStarted 2025-08-04
Plain-language summary
The goal of this clinical trial is to learn if the use of cyanoacrylate glue (PeriAcryl) is effective in healing of the palatal donor site in adults requiring a free gingival graft.
The main question\[s\] it aims to answer \[is/are\]:
Does PeriAcryl accelerate the palatal tissue healing compared with the use of collagen sponge? Does PeriAcryl usage leave the patients more satisfied?
Researcher will compare the outcomes of participants treated with PeriAcryl to those treated with collagen sponge to see if PeriAcryl accelerated the healing process of palatal tissues and led to fewer postoperative complications.
Participants will:
* be assigned to a study group using PeriAcryl or control group using Collagen sponge.
* be followed-up to monitor healing and gather clinical information.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Low-moderate anesthetic risk (ASA I-II)
* No restriction on ethnicity or gender
* Patients requiring FGG from the palate for periodontal plastic surgery
* Clinically healthy gingiva after phase I therapy
* Full-mouth plaque index grades 0 and 1
* Bleeding scores \<15%
Exclusion Criteria:
* Patients who smoke \> 10 cigarettes/day
* Patients with coagulation disorders
* Systemic diseases
* Patients on certain medications that may affect periodontal tissues
* Pregnant and lactating patient
* Patients with allergies to drugs that will be prescribed during the treatment phase
* Pathological mental conditions (dementia, psychosis) and lack of cooperation
* Excessive gag reflex
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Healing of palatal wound
Timeframe: 1 month, 2 months and 3 months post-operatively.
2
Epithelization of the palatal wound
Timeframe: On every follow-up session: 7 days, 14 days, 21 days, 1 month, 2 months and 3 months post-operatively.