Evaluating the Efficacy of Exosome-Enriched Culture Media to Enhance In Vitro Maturation and Embryo Development in Poor Ovarian Responders Undergoing IVF Summary: This is a prospective, randomized controlled trial designed to assess whether supplementing standard IVF culture media with exosomes can improve the short-term in vitro maturation (IVM) of immature MI oocytes in poor ovarian responder patients. Sixty women aged 35-42 who meet Bologna criteria for poor ovarian response will be recruited and randomized into two groups: Control group: MI oocytes cultured in standard IVF media. Intervention group: MI oocytes cultured in IVF media supplemented with 10 µg of GMP-certified exosomes per well. The primary outcome is the proportion of MI oocytes maturing to MII within 4 hours. Secondary outcomes include fertilization rates, embryo quality, blastocyst development, and clinical pregnancy rates. This study aims to explore a novel approach to improving oocyte yield and embryo development in poor responder IVF cycles, potentially reducing the need for repeated treatments and enhancing patient outcomes.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Proportion of MI Oocytes Achieving MII Maturation
Timeframe: Within 4 hours post-culture