Not Yet RecruitingNot Applicable

Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence

64 participantsStarted 2025-09-10

Plain-language summary

This study aimed to evaluate and compare impact of integrating passive ultrasonic activation and laser activation with nano-chitosan and aloe vera in terms of postoperative pain and flare-up incidence in a randomized clinical trial.

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-60 (adults only) * multiple-rooted with multiple root canal. * Permanent teeth with mature apex and complete root formation. * Without root caries. * Tooth must be restorable. * Without anatomical abnormalities such as fusion. * Healthy patient category I according to ASA. * Vital tooth, with acute irreversible pulpitis and without peri-apical periodontitis. * No periapical radiolucency. * Consent Patients for who consent to participate and attend follow-up appointments. Exclusion Criteria: * single root canals or double root. * Root canal calcifications. * Root resorption or fracture. * Previously root canal treated teeth. * immunocompromised patients. * Pregnant females * Patients with systemic diseases as diabetic or hypertension patients. * Patients with facial swelling. * patients who use analgesics or antibiotics within 48-72 hours. * Allergy to any materials used (e.g., irrigants or anesthetics). * psychiatric illness * Teeth that are not indicated for endodontic treatment: bad oral hygiene, mobile teeth, or recessed teeth. * Previously endodontically treated teeth. * Teeth with sinus tract.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

postoperative pain intensity Postoperative pain is to be assessed using visual analog scale (VAS), A scale from (0 to 10) where "0" means no pain and "10 means a severe pain that has never faced before.

Timeframe: [Time Frame: 6, 12, 24, 48, 72 hours and 7 days after the first visit to collect the postoperative pain data.]

Trial details

NCT IDNCT07084194

SponsorMinia University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07-01

Contact for this trial

Rabee Ibrahaim Alhabibi

+201018836570 rabieibrahaim@gmail.com

View on ClinicalTrials.gov More Postoperative Pain trials

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Timeframe: [Time Frame: 6, 12, 24, 48, 72 hours and 7 days after the first visit to collect the postoperative pain data.]