By InvitationPhase 2/3

Evaluation of Tretinoin Cream on the Integrity of Aged Forearm Skin

United States30 participantsStarted 2025-07-14

Plain-language summary

The purpose of this research is to determine whether once nightly application of tretinoin 0.1% cream to forearm skin reduces the frequency of skin tears and bruising (solar purpura), and changes skin thickness over a period of 6 months.

Who can participate

Age range55 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult (55+) * History of skin tears, at least 2 in the past month * History of skin bruising (solar purpura) * Ambulatory * Able to apply topical medication to oneself Exclusion Criteria: * \<55 years old) * Pregnant or breastfeeding * History of allergy to tretinoin * History of atopic dermatitis, psoriasis, bullous skin disease, cutaneous lupus, or cutaneous T cell lymphoma. * Planned cutaneous surgery on either forearm in the next 6 months * Use of any topical medication on the forearms within past month * Current or anticipated phototherapy of the forearms in the next 6 months * Current or anticipated chemotherapy within the next 6 months * Use of oral steroids within past month * Current or prior isotretinoin therapy within past 6 months * AV fistula of the arm

What they're measuring

Change in frequency of skin tears.

Timeframe: 6 months.

Change in epidermal (top layer of skin) thickness.

Timeframe: 6 months.

Trial details

NCT IDNCT07084116

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-01

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