Evaluation of Tretinoin Cream on the Integrity of Aged Forearm Skin (NCT07084116) | Clinical Trial Compass
CompletedPhase 2/3
Evaluation of Tretinoin Cream on the Integrity of Aged Forearm Skin
United States15 participantsStarted 2025-07-14
Plain-language summary
The purpose of this research is to determine whether once nightly application of tretinoin 0.1% cream to forearm skin reduces the frequency of skin tears and bruising (solar purpura), and changes skin thickness over a period of 6 months.
Who can participate
Age range
55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult (55+)
* History of skin tears, at least 2 in the past month
* History of skin bruising (solar purpura)
* Ambulatory
* Able to apply topical medication to oneself
Exclusion Criteria:
* \<55 years old)
* Pregnant or breastfeeding
* History of allergy to tretinoin
* History of atopic dermatitis, psoriasis, bullous skin disease, cutaneous lupus, or cutaneous T cell lymphoma.
* Planned cutaneous surgery on either forearm in the next 6 months
* Use of any topical medication on the forearms within past month
* Current or anticipated phototherapy of the forearms in the next 6 months
* Current or anticipated chemotherapy within the next 6 months
* Use of oral steroids within past month
* Current or prior isotretinoin therapy within past 6 months
* AV fistula of the arm
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in frequency of skin tears.
Timeframe: 6 months.
2
Change in epidermal (top layer of skin) thickness.