RecruitingNot Applicable

Short-Term Atrial Pacing and Hemodynamics After Cardiac Surgery

Lebanon200 participantsStarted 2025-08-04

Plain-language summary

The goal of this clinical trial is to learn whether temporary atrial pacing improves heart function after cardiac surgery under cardiopulmonary bypass (CPB). It will also help determine the best pacing rate during the first 24 hours after surgery. The main questions it aims to answer are: * Does atrial pacing improve cardiac output after surgery? * Is 70, 80, or 90 bpm the most effective pacing rate? * Does pacing reduce the risk of atrial fibrillation after surgery?

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients aged 18 years or older * Cardiac surgery under CPB (coronary artery bypass grafting, valve replacement or repair, or combined procedures) * Placement of epicardial atrioventricular pacing wires during surgery * Placement of a Swan-Ganz catheter intraoperatively * Signed informed consent Exclusion Criteria: * Emergency surgery * Patients with an internal pacemaker * History of permanent atrial fibrillation * Complete atrioventricular block upon weaning from CPB * Junctional rhythm upon weaning from CPB * Sinus rhythm \< 50 bpm upon weaning from CPB * Failure of atrial or dual-chamber pacing (patients paced in ventricular mode VVI) * Contraindication to Swan-Ganz catheter placement * Hemodynamic instability defined by significant bleeding or tamponade requiring surgical re-intervention, or the need for escalating doses of vasopressors (Norepinephrine \> 1 μg/kg/min, Dobutamine \> 10 μg/kg/min)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Evaluate the impact of different pacing rates on cardiac index measured by Swan-Ganz catheter in the postoperative period following cardiac surgery under cardiopulmonary bypass at H0, H6, H12, and H24.

Timeframe: 24 hours after the surgery

Trial details

NCT IDNCT07082283

SponsorSaint-Joseph University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-30

Contact for this trial

Rhea Mattar

+96171464840 rhea.mattar@net.usj.edu.lb

View on ClinicalTrials.gov More Cardiac Output trials