Evaluation of the Effects on Carbon Dioxide (paCO2) of a New Oronasal Mask in Patients With Severe COPD Exacerbation Requiring Non-Invasive Mechanical Ventilation

Inclusion Criteria: * Age ≥ 18 years * Informed consent obtained * Patients with COPD and acute hypoxemic-hypercapnic respiratory failure (pH \< 7.35, PaO₂ \< 60 mmHg, PaCO₂ \> 45 mmHg) requiring non-invasive mechanical ventilation. Exclusion Criteria: * BMI ≥ 30 kg/m² * Obstructive sleep apnea syndrome * Neuromuscular diseases or chest wall pathologies * Need for intubation and invasive mechanical ventilation during exacerbation * Use of home non-invasive mechanical ventilation or CPAP * Contraindications for NIV * Cognitive disorders that may interfere with adherence to treatments * Patients with active and unstable coronary artery disease * Previous esophageal surgery, known esophageal stenosis, or any other condition that could put the patient at risk during the placement of the respiratory mechanics probe