Not Yet RecruitingNot Applicable

Low Level Laser VS Transcutaneous Vagus Nerve Stimulation on Vascular Changes in Patients With Diabetic Polyneuropathy

Egypt30 participantsStarted 2025-08-01

Plain-language summary

To compare the effect of both low-level laser versus transcutaneous vagus nerve stimulation on vascular changes in patients with diabetic polyneuropathy

Who can participate

Age range45 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. 30 patients diagnosed with diabetic neuropathy from both genders their ages will be ranged from 45-60 years old.
✓. All patients are ambulant independently.
✓. All patients are under full medical control
✓. Glycated hemoglobin is ranged from 6.5: 7 %.
✓. Patients have had diabetes for more than 5 or 10 years.
✓. patients experiencing painful peripheral neuropathic symptoms for more than 6 months involving both lower extremities and complained of burning pain with paresthesia in both legs.

Exclusion criteria

✕. Patients had unstable glycemic control and/or medical conditions that would confound assessment of neuropathy such as malignancy, active/untreated thyroid disease, peripheral vascular diseases, vascular insufficiency (claudication, skin discoloration, ulceration).
✕. Following the implantation of cardiac pacemakers or other electrical stimulation devices.
✕. Patient had sinus bradycardia, long QT syndrome, or other arrhythmias or mental disorders.
✕. Patients whose heart rate dropped below 50 beats/min after vagus nerve stimulation.
✕. Nerve damage as a result of prior reconstructive or replacement knee surgery, back surgery, spinal stenosis, spinal compression or radiculopathy

What they're measuring

assessment of change of vascular blood flow

Timeframe: at baseline and after 8 weeks

Trial details

NCT IDNCT07078058

SponsorHorus University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-01

Contact for this trial

Manar Elbaz Mohamed nasr, Assistant lecturer

01008805149 melbaz@horus.edu.eg

View on ClinicalTrials.gov More Low Level Laser trials