EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases (NCT07077304) | Clinical Trial Compass
RecruitingNot Applicable
EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases
France5,000 participantsStarted 2025-11-19
Plain-language summary
Inflammatory Cardiovascular Diseases and Autoimmune Rheumatic Diseases (ICARDs) encompass cardiovascular involvement in connective tissue diseases, vasculitis, and primary inflammatory cardiac processes affecting all layers of the heart. ICARDs are associated with increased cardiovascular morbidity and mortality, independently of traditional risk factors, via multiple pathophysiological mechanisms.
Diagnosis and prognosis are challenged by the heterogeneity of clinical presentations. Multimodality cardiovascular imaging - including cardiovascular magnetic resonance (CMR), transthoracic echocardiography, and positron emission tomography (PET) - plays a central role in detecting and characterizing inflammatory involvement, and may offer prognostic insights.
Given the limited data on the diagnostic and prognostic utility of these imaging modalities in ICARDs, the EACVI-INFLAME study aims to assess the prevalence of confirmed cardiovascular involvement in patients with suspected or established ICARDs undergoing CMR and/or cardiac PET in a multicentric international cohort.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age ≥ 18 years
. Ability to provide informed non-opposition
. Referred for a CMR and/or nuclear imaging exam
. Suspected Myocarditis (acute or chronic, and whatever the aetiologies)
. Suspected Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA)
. Suspected Tako-Tsubo
. Suspected Pericarditis (acute or chronic, and whatever the aetiologies)
. Suspected Connective tissue disease with cardiovascular involvement:
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this study is focused on imaging patients who are already being referred for cardiac MRI or nuclear imaging, is that something you were already planning to order for me, and could my scheduled imaging be done as part of this study?
2This trial is measuring how often cardiovascular involvement is actually confirmed in people with conditions like mine — does that mean my results would contribute to helping doctors better understand how diseases like mine affect the heart?
3Because this is a non-interventional imaging study with no assigned phase, it seems like it's observational rather than testing a new treatment — can you help me understand what, if anything, would be different about my care if I participated versus just having the imaging done outside the study?
4Given that my condition is one of several being studied together — including myocarditis, lupus, sarcoidosis, and others — would my imaging be interpreted the same way it would be in standard care, or would there be any additional scans or procedures I'd need to do specifically for the research?
5If the study confirms that I do have cardiovascular involvement, would that finding directly influence my treatment plan, or would it primarily be used for research purposes?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of patients with confirmed cardiovascular involvement among consecutive patients with a suspicion of cardiovascular involvement due to a suspected or known ICARD referred for CMR and/or nuclear imaging exam.
Timeframe: At each diagnostic assessment point, up to study completion, an average of 1 year.