CompletedNot Applicable

Topical Icariin on Acne and Acne Scars

South Korea25 participantsStarted 2023-03-21

Plain-language summary

The goal of this clinical trial is to examine whether topical application of icariin can improve acne and atrophic acne scars in adults. The main questions it aims to answer are: * Does icariin reduce the number of facial acne lesions and acne scars? * What histological changes occur in acne or scar tissue after using icariin? Researchers will compare icariin to a vehicle control (3% ethanol solution) to assess its relative efficacy. Participants will: * Apply icariin or control solution to each side of the face twice daily for 2 months * Visit the clinic every 4 weeks for checkup * Receive skin biopsies before and after the study period, if they consent to this procedure

Who can participate

Age range19 Years – 39 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 19 to 39 with inflammatory acne and atrophic acne scars on both sides of the face Exclusion Criteria: * Diagnosis of acne conglobata or acne fulminans * Pregnancy or breastfeeding * Presence of systemic diseases or use of medications that may affect acne or scarring * Presence of psychiatric disorders * Recent use of isotretinoin within the past 4 months * Use of other oral or topical acne treatments or anti-acne cosmetics within the past 2 weeks * Receipt of procedural treatment for acne scars (e.g. chemical peels or energy-based devices) within the past 4 weeks

What they're measuring

Change from baseline in the total number of acne lesions and scars at 8 weeks

Timeframe: From enrollment to the end of treatment at 8 weeks

Trial details

NCT IDNCT07076784

SponsorSeoul National University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-31

View on ClinicalTrials.gov More Acne trials