The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of consciousness resulting from acute brain injury. The main questions this study aims to answer are: How do functional MRI findings (e.g., covert consciousness and network connectivity) associate with current level of consciousness? How do functional MRI findings (e.g., covert consciousness and network connectivity) associate with future recovery of consciousness? How does noxious stimulation affect the detection of covert consciousness and functional brain network connectivity?
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Detection of technologic covert consciousness
Timeframe: Baseline, during hospitalization (estimated approximately 1 month from brain injury)
Functional network connectivity
Timeframe: Baseline, during hospitalization (estimated approximately 1 month from brain injury)
Detection of behavioral covert consciousness
Timeframe: Baseline, during hospitalization (estimated approximately 1 month from brain injury), within 24 hours of the functional MRI
Overt consciousness recovery based on Disability Rating Scale
Timeframe: Through study completion: At hospital discharge (estimated approximately 1 month from brain injury), 3 months after hospital discharge, and 6 months after hospital discharge