Not Yet RecruitingEarly Phase 1

Clinical Performance and Remineralization Potential of Self- Assembling Peptide P11-4 Containing Fluoride Versus Er, Cr: YSGG Laser Treatment and Micro Tensile Bond Strength of Giomer Restoration in Carious Lesions

21 participantsStarted 2025-09-15

Plain-language summary

This study will be performed in two parts, in vivo and in vitro to assess the effect of the remineralization potential of self-assembling peptide P11-4 containing Fluoride on caries-affected dentin compared to untreated caries-affected dentin and the influence of Er, Cr: YSGG Laser treatment.

Who can participate

Age range20 Years – 40 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * o Patients aged (20 - 40) years. * Presence of at least one posterior permanent molar with an occlusal carious lesion classified as ICDAS code 3 or 4 requiring operative treatment. * Good general and oral health. * Willingness to participate and provide informed consent. Exclusion Criteria: * o Patients with systemic conditions affecting oral health or healing. * Teeth with pulp involvement or periapical pathology. * Allergy to study materials. * Poor oral hygiene or periodontal disease in the target tooth region.

What they're measuring

Marginal integrity of restorations

Timeframe: 6 months and 12 months

Clinical longevity of restorations

Timeframe: 6 and 12 months

Overall clinical performance of restorations

Timeframe: 6 and 12 months

Trial details

NCT IDNCT07065305

SponsorAl-Azhar University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09-15

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