CompletedNot Applicable

The Effect of Heat Exposure on Physiological Markers

Lithuania11 participantsStarted 2021-01-11

Plain-language summary

This study is the first to examine the effects of core temperature elevation on kynurenine pathway (KP) metabolites in healthy young males. It was hypothesized that rise in core temperature due to both pasive heating and exercise will initiate a stress response, affecting the concentration of KP metabolites. Additionally, it was expected that the exercise would produce more pronounced effects due to the increased cardiovascular, mechanical, and metabolic demands associated with it. Thus, the the main purpose of the present study was to investigate and to compare the effects of two distinct heat stress modalities on KP metabolites.

Who can participate

Age range18 Years – 36 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * healthy adults; * age between 18 - 36 years; * physically active (exercising 2-3 times per week); * non-smoking. Exclusion Criteria: * a body mass index (BMI) \> 30 kg/m2; * neurological, cardiovascular, metabolic, and/or inflammatory diseases, or conditions that could be worsened by exposure to interventions and that could affect experimental variables; * involvement in temperature manipulation program for ≥ 3 months.

What they're measuring

Change in plasma metabolites of the kynurenine pathway (μm)

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Rectal temperature (°C)

Timeframe: Day 1 (during both heating modalities until Tre reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Change in heart rate (bpm)

Timeframe: Day 1 (during both heating modalities until Tre reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Change in physiological strain index

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Change in glucose (mmol/L)

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Change in lactate (mmol/L)

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Changes in prolactin concentration (ng/mL)

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Trial details

NCT IDNCT07064512

SponsorLithuanian Sports University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-03-12

View on ClinicalTrials.gov More Healthy Adult Male trials

Plain-language summary

Who can participate

Age range18 Years – 36 Years

SexMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in plasma metabolites of the kynurenine pathway (μm)

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Rectal temperature (°C)

Timeframe: Day 1 (during both heating modalities until Tre reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Change in heart rate (bpm)

Timeframe: Day 1 (during both heating modalities until Tre reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Change in physiological strain index

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Change in glucose (mmol/L)

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Change in lactate (mmol/L)

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)

Changes in prolactin concentration (ng/mL)

Timeframe: Day 1 (every 0.5 °C until rectal temperature (Trec) reached 39°C, followed by a recovery phase until Trec reached 37.5°C)