Microplastics in Paraneoplastic and Intratumoral for Colorectal Cancer (NCT07063550) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Microplastics in Paraneoplastic and Intratumoral for Colorectal Cancer
China100 participantsStarted 2024-12-01
Plain-language summary
The objective of this study is to identify and characterize microplastics present in peritumoral and intratumoral tissues of colorectal cancer patients, and to investigate their associations with gut microbiome composition and metabolic profiles. By integrating microplastic analysis with metagenomic and metabolomic data, we aim to explore the potential impact of environmental microplastic exposure on tumor microenvironment alterations, microbial dysbiosis, and metabolic reprogramming in colorectal cancer.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients (≥18 years old) with histologically confirmed colorectal adenocarcinoma.
* Undergoing elective radical colorectal cancer resection at the study hospital.
* No prior chemotherapy, radiotherapy, or targeted therapy before surgery.
* Availability of both tumor tissue and adjacent normal (peritumoral) tissue samples during surgery.
* Willingness to provide stool and/or blood samples for metagenomic and metabolomic analysis.
* Ability to understand the study procedures and provide written informed consent.
Exclusion Criteria:
* Patients with a history of other malignancies within the past 5 years.
* Emergency surgery due to obstruction, perforation, or bleeding.
* Inadequate sample quality or volume for microplastic, metagenomic, or metabolomic analysis.
* Presence of chronic inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis).
* Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to sample collection.
* Pregnant or breastfeeding women.
* Refusal or inability to provide informed consent.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
genomics
Timeframe: Blood specimens were obtained within one week prior to surgery.