Effect of Aerobic Exercise on Biomarkers in Depression (NCT07062783) | Clinical Trial Compass
CompletedNot Applicable
Effect of Aerobic Exercise on Biomarkers in Depression
Turkey (Türkiye)40 participantsStarted 2024-08-01
Plain-language summary
This study aims to investigate changes in the levels of biomarkers (IGF-1, FGF2, and EGF) involved in neuron development in patients diagnosed with major depression through the effects of breathing exercises and aerobic exercise, as well as to examine the levels of biomarkers (TNF-α, IL-6, and IL-1) and oxidative stress (TAS, TOS, MDA, and F2-isoprostane) that are thought to play a role in the pathophysiology of depression.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Individuals who volunteer to participate in the study,
* Between the ages of 18 and 40,
* Have been diagnosed with clinical depression by a psychiatrist according to DSM-5 criteria
Exclusion Criteria:
* Individuals with chronic conditions accompanying depression,
* Those with walking difficulties
* Those with respiratory system disorders
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study looked at aerobic exercise and its effect on oxidative stress and inflammatory markers in people with major depression — what do those biomarkers actually mean for my condition, and is there any evidence from this completed trial that my doctor has seen?
2Since this trial is already completed and wasn't testing a drug but rather aerobic exercise, is there anything from its findings that might already apply to my current treatment plan?
3The trial measured 'proinflammatory cytokines' — can you explain whether inflammation is thought to play a role in my specific case of depression, and whether that changes what treatments might work best for me?
4Given that this was a non-drug study on exercise, how does aerobic activity fit alongside any medication or therapy you're already recommending for me, and are there any risks I should know about before increasing my exercise level?
5Are there published results from this completed trial that you could review together with me, to help us understand whether its findings about exercise and depression biology are relevant to my situation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Oxidative stress biomarkers
Timeframe: From enrollment to the end of treatment at 3 weeks
2
Proinflmatuar sytokines
Timeframe: From enrollment to the end of treatment at 3 weeks