CompletedNot Applicable

Comparative Effects of Exercise and Metformin on Glycemic Control in Prediabetic Adults

Pakistan226 participantsStarted 2025-08-10

Plain-language summary

This study is being done to compare the effect of regular exercise and metformin in people who have prediabetes. It is a community-based, open-label, randomized trial in which eligible participants will be divided into two groups. One group will do moderate physical exercise, and the other group will take metformin for 12 weeks. We will check their fasting blood sugar and HbA1c before and after the treatment to see which method works better for controlling sugar levels. The study is being done in a low-resource community setup to see which option is more practical and effective in real-life Pakistani settings.

Who can participate

Age range18 Years – 59 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18 to 59 years * Diagnosed with prediabetes based on ADA criteria (FPG: 100-125 mg/dL or HbA1c: 5.7-6.4%) * Stable HbA1c levels (no significant fluctuation in the last 3 months) * Body Mass Index (BMI) less than 30 kg/m² * Willing and able to provide written informed consent * Willing to participate in the assigned intervention (exercise or metformin) for 12 weeks * Residing within the community and able to attend scheduled follow-ups Exclusion Criteria: * Age 60 years or older * Diagnosis of Type 2 Diabetes Mellitus (T2DM) or use of anti-diabetic medications * Family history of diabetes in first-degree relatives (parent or sibling) * Known cardiovascular, renal, or hepatic disease * Pregnancy or lactation * Physical disability or limitation that would interfere with performing moderate-intensity exercise * Uncontrolled hypertension (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg) * Known allergy or contraindication to metformin * Alcohol or substance abuse

What they're measuring

Change in Glycated Hemoglobin (HbA1c) from Baseline to 12 Weeks

Timeframe: Baseline and 12 week

Trial details

NCT IDNCT07061496

SponsorAsad Ullah Jan

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2026-02-15