Comparative Effects of Exercise and Metformin on Glycemic Control in Prediabetic Adults (NCT07061496) | Clinical Trial Compass
CompletedNot Applicable
Comparative Effects of Exercise and Metformin on Glycemic Control in Prediabetic Adults
Pakistan226 participantsStarted 2025-08-10
Plain-language summary
This study is being done to compare the effect of regular exercise and metformin in people who have prediabetes. It is a community-based, open-label, randomized trial in which eligible participants will be divided into two groups. One group will do moderate physical exercise, and the other group will take metformin for 12 weeks. We will check their fasting blood sugar and HbA1c before and after the treatment to see which method works better for controlling sugar levels. The study is being done in a low-resource community setup to see which option is more practical and effective in real-life Pakistani settings.
Who can participate
Age range
18 Years – 59 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 to 59 years
* Diagnosed with prediabetes based on ADA criteria (FPG: 100-125 mg/dL or HbA1c: 5.7-6.4%)
* Stable HbA1c levels (no significant fluctuation in the last 3 months)
* Body Mass Index (BMI) less than 30 kg/m²
* Willing and able to provide written informed consent
* Willing to participate in the assigned intervention (exercise or metformin) for 12 weeks
* Residing within the community and able to attend scheduled follow-ups
Exclusion Criteria:
* Age 60 years or older
* Diagnosis of Type 2 Diabetes Mellitus (T2DM) or use of anti-diabetic medications
* Family history of diabetes in first-degree relatives (parent or sibling)
* Known cardiovascular, renal, or hepatic disease
* Pregnancy or lactation
* Physical disability or limitation that would interfere with performing moderate-intensity exercise
* Uncontrolled hypertension (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg)
* Known allergy or contraindication to metformin
* Alcohol or substance abuse
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Glycated Hemoglobin (HbA1c) from Baseline to 12 Weeks