Comparative Evaluation of Guava Leaf Extract and Chlorhexidine Mouthwash in Patients With Chronic… (NCT07059572) | Clinical Trial Compass
CompletedNot Applicable
Comparative Evaluation of Guava Leaf Extract and Chlorhexidine Mouthwash in Patients With Chronic Gingivitis
Bangladesh160 participantsStarted 2025-05-27
Plain-language summary
The goal of this clinical trial is to compare the effectiveness of 0.15% guava (Psidium guajava) leaf extract mouth rinse with 0.2% Chlorhexidine (CHX) mouth rinse in reducing plaque accumulation, gingival inflammation, and oral microbial load in participants with plaque-induced chronic moderate or severe gingivitis. Half of the participants will receive guava leaf extract mouth rinse, and the other half will receive Chlorhexidine(CHX).
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria: • Participants with a minimum of 24 functional teeth.
* Presence of Plaque induced chronic moderate to severe form of gingivitis.
* Participants within the age group of 18 to 35 years.
* Willing and able to comply with all study procedures.
Exclusion Criteria: • Pregnant or lactating women.
* Systemically compromised people; subjects with removable or fixed orthodontic appliances or prosthesis.
* People who were prescribed antibiotics or inflammatory drugs in the past 1 month.
* History of smoking or any form of tobacco use.
* History of allergic reactions to Chlorhexidine or Guava.
* Severe systemic conditions that could contraindicate participation in the study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Plaque Index
Timeframe: At baseline, 1 month, and 3 months post-intervention
2
Change in Gingival Index (GI)
Timeframe: At Baseline, 1 Month, and 3 Months post-intervention
Trial details
NCT IDNCT07059572
SponsorBangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh