Safety Study of a Single Dose of Pneumococcal Whole-Cell Vaccine in Healthy Adults

Inclusion Criteria: * Adult aged \> 18 and \< 49 years at screening. * Body mass index (BMI) ≥ 18.0 and ≤ 30.0 kg/m2, with a maximum body weight of 120 kg at screening. * Good general health, without significant medical illness or abnormal physical examination, or laboratory findings per PI discretion. * If female, not breastfeeding, not pregnant, and not planning pregnancy during study period. * If female of child-bearing potential, willing to use acceptable method of contraception. * Willing and able to comply with all study activities, assessments, and restrictions through 30 days of follow-up. Willing and able to be contacted reliably by phone, and willing for the study team to record phone voice messages as needed. * Provided written informed consent to participate in the clinical trial before any study-related activities are carried out and, in the PI's opinion, must be able to understand the full nature and purpose of the trial, including possible risks and adverse effects. Exclusion Criteria: In addition to meeting the inclusion criteria, individuals will be excluded from this trial if they meet any of the following exclusion criteria: * History or presence of clinically significant medical condition or disease, including (but not limited to) clinically significant cardiovascular, pulmonary, hepatic, renal, gastrointestinal, endocrine, hematologic, immunologic, oncologic, rheumatologic, dermatologic, neurological or psychiatric disease. * History of known invasive…