A Study of Exercise and Pharmacologic Intervention on Systemic Inflammation

Inclusion Criteria: * Patients 65-80 years old * Current or former smokers * BMI 25-32 * No cancer requiring active therapy within the last 2 years * No autoimmune disease requiring disease modifying agents * No patients with CKD stage 3/4 or ESRD * No class 3 or 4 heart failure Exclusion Criteria: * Patients may not have cancer requiring active therapy within the last 2 years * Patients may not have autoimmune disease requiring disease modifying agents * Patients may not be receiving immune modifying biologic therapies * Patients may not have chronic kidney disease stage 3/4 or end stage renal disease * Patients may not have a known history of metabolic dysfunction-associated steatohepatitis * Patients may not have a known chronic viral infection such as HIV or active Hepatitis B or C, or a known history of genital HSV. Patients who have spontaneously or through treatment cleared hepatitis B or C are candidates for the trial. If Hepatitis B core ab is positive must document a negative PCR. * Patients may not have class 3 or 4 heart failure, or have experienced a myocardial infarction or cerebrovascular event in the past 6 months * Patients may not have uncontrolled diabetes mellitus * Patients may not have a history of clinically significant interstitial lung disease (ILD). * Patients may not have clinically significant active wound healing due to recent injury or surgery * Patients may not have signs or symptoms of clinically significant acute infectious illness on scree…