Evaluation of Post-Operative Pain Following the Use of Nano-Calcium Hydroxide (NCT07057336) | Clinical Trial Compass
CompletedNot Applicable
Evaluation of Post-Operative Pain Following the Use of Nano-Calcium Hydroxide
Turkey (Türkiye)90 participantsStarted 2024-05-14
Plain-language summary
The goal of this clinical trial is to evaluate the effect of different intracanal medicaments-conventional calcium hydroxide (CH) and nano-sized calcium hydroxide (NCH)-on the intensity of postoperative pain following root canal treatment in asymptomatic necrotic single-rooted teeth.
The primary research question of this study is as follows:
Does the use of nano-sized calcium hydroxide, compared to conventional calcium hydroxide, result in significantly reduced postoperative pain after root canal treatment?
In both groups, standardized instrumentation will be performed using rotary NiTi files and 2.5% sodium hypochlorite irrigation. After cleaning and shaping, canals will be medicated with either CH or NCH, followed by temporary sealing.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 18-65 years
* Single-rooted permanent maxillary or mandibular teeth
* Asymptomatic teeth with necrotic pulps confirmed by negative response to cold test
* Presence of periapical radiolucency (PAI score 2-5)
* No sensitivity to percussion or palpation
* Patients who signed informed consent
Exclusion Criteria:
* Pregnancy or lactation
* Systemic diseases requiring antibiotic prophylaxis (e.g., infective endocarditis, immunosuppression)
* Use of antibiotics, corticosteroids, or analgesics within the past 7 days
* History of chemotherapy or radiotherapy
* Uncontrolled diabetes mellitus or hypertension
* Chronic renal failure, hematologic disorders
* Teeth with root resorption, previous endodontic treatment, or multirooted anatomy
* Teeth with periodontal pockets \>4 mm or mobility
* Inability to attend follow-up visits
* Patients with extensive coronal destruction rendering definitive restoration unfeasible
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.