Simultaneous Engagement of Networks for Alleviating Pain (SENAP)

Inclusion Criteria: * Age ≥ 22 years * Clinical diagnosis of a refractory chronic neuropathic pain syndrome suggestive of deafferentation or central pain. Non-limiting examples of these syndromes are: * post-traumatic pain syndromes (e.g. plexopathies, radiation-induced injury) * postsurgical pain syndromes (e.g. phantom limb pain, anesthesia dolorosa) * postherpetic neuralgia * Central pain syndromes (e.g. post-stroke pain, multiple sclerosis pain, post-radiation pain) * Greater than 6 months of chronic neuropathic pain * Average pain intensity over the past 30 days reported as 6 or greater on a 0-10 numeric rating scale (NRS) * Multidisciplinary pain consensus review that establishes * Pain is refractory to medical management * Pain that is refractory to or unlikely to be altered by less invasive treatment and * Pain distribution either does not permit attempts at relief by a targeted nerve block (e.g., post-stroke pain) or such blocks have provided \<25% relief. * Medication doses currently stable (no active titration or drug trials in progress) in the 30 days prior to baseline (immediately pre-surgical) study visit * Ability to speak / read English * Capable of understanding and providing informed consent (verified if necessary by a standard tool such as the MacArthur Competency Assessment) * Women of childbearing age must be on regular use of an accepted contraceptive method(s). Exclusion Criteria: * Pregnancy, breastfeeding, or unwilling to maintain regular use of co…