CompletedNot Applicable

Multi-modal Medical Images for Extraocular Muscle Fibrosis Assessment

China58 participantsStarted 2020-01-01

Plain-language summary

The purpose of this study was to evaluate the elasticity of the extraocular muscles in different stages of thyroid eye disease and to examine the correlation of MRI parameters (native T1 value and ECV) and elasticity for the assessment of extraocular muscles fibrosis in the thyroid eye disease.

Who can participate

Age range

20 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Consecutive patients with moderate-to-severe TED were retrospectively enrolled from Tianjin Eye Hospital between 2020 and 2024. Exclusion Criteria: Participants who reported any of the following were excluded: (1) any ophthalmopathies (e.g., glaucoma, diabetic retinopathy and optic nerve disorders); (2) patients with dysthyroid optic neuropathy (DON).

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

MRI parameters (native T1 value and ECV) and elasticity of EOMs in the TED.

Timeframe: Consecutive patients with moderate-to-severe TED were retrospectively enrolled from Tianjin Eye Hospital between 2020 and 2024. All patients underwent MR with T1 mapping and RTE. The patients were categorized into either the active or inactive TED

Trial details

NCT IDNCT07056114

SponsorTianjin Eye Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-01

View on ClinicalTrials.gov More Thyroid Eye Disease, TED trials