Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy

Inclusion Criteria: * 35-75 years * The symptoms and signs are consistent with acute anterior circulation ischemic stroke. The immediate postoperative angiographic recanalization grade was ≥ 2b. * Neurological deficit score at the time of enrollment: 5 ≤ NIHSS ≤ 15 points * Consciousness status (NIHSS 1a-1b items): 0-1 point * Pre-stroke functional status (mRS score): 0-1 * Time from surgery to randomization grouping: ≤ 72 hours * Patient or legal representative who signed the informed consent form * Preoperative CT angiography or magnetic resonance angiography confirmed large vessel occlusion (internal carotid artery or middle cerebral artery M1 segment) that was consistent with the symptoms and signs; And the area supplied by the middle cerebral artery in the brain is less than 1/3. * A lberta S troke P rogram E arly C T S core ≥ 6 Exclusion Criteria: * Subjects with HBO contraindications or intolerance * Postprocedural imaging identified either procedure-related subarachnoid hemorrhage or hemorrhagic transformation * Based on the medical history, it is suspected that the cerebral embolism is caused by sepsis or infective endocarditis * Expected lifespan \< 90 days * Severe heart, liver and kidneys failure * Pregnancy * Hereditary or acquired bleeding tendency, deficiency of coagulation factors, recent use of oral anticoagulants with an international normalized ratio (INR) \> 3 or activated partial thromboplastin time (APTT) exceeding the normal value by more than 3 time…