The role of perioperative IV administration of nimodipine, an L-type calcium channel antagonist which is capable of crossing the blood-brain barrier, on peri-operative opioid and anesthetics requirements, pain intensity, opioid-related side effects and early postoperative bowel mobility in patients undergoing surgical treatment for bowel cancer with open radical colectomy remains scarcely explored. A prospective double-blind, randomized controlled trial investigating the effect of perioperative IV administration of nimodipine in patients undergoing open colectomy for cancer treatment is therefore conducted.
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Intraoperative Remifentanil Consumption
Timeframe: Intraoperative period, defined as the time (in minutes) from induction of general anesthesia to extubation.
Intraoperative propofol consumption
Timeframe: Intraoperative period, defined as the time (in minutes) from induction of general anesthesia to extubation.
Cumulative opioid consumption within 0 to 72 hours postoperatively
Timeframe: From Post Anesthesia Care Unit (PACU) admission (time zero) to 72 hours postoperatively.