MRI Evaluation of Graft Maturation Following ACL Reconstruction (NCT07046000) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
MRI Evaluation of Graft Maturation Following ACL Reconstruction
United States10 participantsStarted 2026-08-01
Plain-language summary
Post-surgical ACL Graft maturation will be assessed at 4.5, 6, 7.5, 9, 10.5, and 12 months with MRI.
Who can participate
Age range
14 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* ACL tear and reconstruction; no other knee ligaments needing reconstruction
* Primary (first-time) ACL tear in the affected knee
* ACL injury occurred less than 12 months before ACL reconstruction
* Have no contraindications or allergies to the treatment administered
* Have current imaging studies (plain radiographs and MRI exams within the past 12 months) of the knee to rule out other etiologic diagnoses
* Patient underwent ACL reconstruction with a Bone-Patellar Tendon-Bone (BTB) graft harvested from the same knee (ipsilateral autograft) with the Active Matrix tissue
* Able and willing to comply with the post-operative study follow-up schedule
Exclusion Criteria:
* Prior surgery on the index knee within 12 months of enrollment
* Steroid injection into the index knee within 6 weeks of enrollment
* Chronic ACL tear whereas the injury occurred more than 12 months ago
* Multiligamentous injuries whereas any ligament (MCL, PCL, or PLC) in addition to the ACL needs to be reconstructed
* Patient underwent ACL reconstruction with a hamstring tendon, Achilles tendon or quadriceps tendon graft (any graft other than a patellar tendon BTB)
* Contraindication to MRI (eg, implanted devices incompatible with MRI).
* Chrondral lesion of the knee that requires treatment during ACL reconstruction surgery
* History of advanced osteoarthritis of the knee or patella-femoral joint; KL grade III or higher
* History of malignant tumor and osseous metastatic disease,
* Hist…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Graft Maturation via MRI
Timeframe: From 4.5 months post surgery until 12 months or graft maturation.