CompletedNot Applicable

Microbiome Modulation by PEMF on Plaque Induced Mucositis in Human Jaws

Brazil35 participantsStarted 2025-05-11

Plain-language summary

To evaluate the impact of Pulsed Electromagnetic Field (PEMF) on mucositis induced in humans around dental implants and correlate these possible effects with the proteomic profile of implants with and without PEMF and teeth. The hypothesis is that PEMF may modulate bacterial biofilm formation around dental implants and enhance the host response following plaque-induced peri-implant mucositis. Secondary analysis will be the increase in the soft tissue volume using Intra-oral scanning (IOS).

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: -healthy individuals over 18 years of age * have at least 2 contiguous edentulous spaces * more than 15 teeth * have not undergone periodontal treatment for at least 6 months before the start of the study Exclusion Criteria: - Individuals with extensive dental restorations; * with periodontal disease stages II to IV * with peri-implantitis and/or mucositis (Shibli et al. 2015); * individuals requiring previous grafting for implant insertion; * diabetics; * smokers or former smokers; * pregnant women; lactating women; * use of antibiotics or oral antiseptics in the last 6 months .

What they're measuring

Number of clusters of microorganism

Timeframe: time points 0, 3, 6, 7, 14, 21, 28, 42, and 60 days

Trial details

NCT IDNCT07045636

SponsorJamil awad shibli

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-11

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