Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery (NCT07044089) | Clinical Trial Compass
RecruitingNot Applicable
Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery
Turkey (Türkiye)86 participantsStarted 2025-07-23
Plain-language summary
Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery.
Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy
* Patients between the ages of 18 and 70
* ASA (American Society of Anesthesiologists) physical status classification II-III
Exclusion Criteria:
* Patients with an ejection fraction below 35%
* Patients who did not consent to participate in the study
* Patients undergoing emergency surgery
* Patients who are allergic to the anesthetic drugs used
* Patients who have undergone lung resection
* Those with a history of mechanical ventilation in the 2 months before surgery
* Patients who have undergone total circulatory arrest and deep hypothermia
* Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance
* Morbid obesity (Body Mass Index\>35kg/m2)
* Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation)
* COPD (FEV1\<70%)
* Patients with chronic renal failure (serum creatine\>1.8 mg/dl)
* Anemia (Hg\<10 gr/dl)
* Patients who have had an intraaortic balloon pump placed.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Effects on intraoperative oxygenation, hemodynamics, lung compliance and airway pressures