The goal of this study is to learn what the impact of exposure to virtual reality content is on the levels of stress-related blood values in healthy volunteers. The main question it aims to answer is: * To compare the levels of stress-related biomarkers before and after relaxing VR-content (Relax Visit); * To compare the levels of stress-related biomarkers before and after stress-inducing VR-content (Rollercoaster Visit). Researchers will compare the Relax and Rollercoaster Visit to see if there is a relationship between the relaxing and stress-inducing VR content on stress-related blood values. Participants will be asked to watch relaxing or stress-inducing VR content for approximately five minutes. Blood will be withdrawn before and after intervention. After 3-5 weeks the study visit will be repeated using the other VR content.
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The effect of relaxing VR content on von Willebrand ristocetin co-factor activity
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on von Willebrand ristocetin co-factor activity
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on von Willebrand ristocetin co-factor activity
Timeframe: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on FVIII activity
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on FVIII activity
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on FVIII activity
Timeframe: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on copeptin
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on copeptin
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on copeptin
Timeframe: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on prolactin
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on prolactin
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on prolactin
Timeframe: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on thyroid stimulating hormone (TSH)
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on TSH
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on TSH
Timeframe: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on cortisol
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on cortisol
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on cortisol
Timeframe: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on glucose
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on glucose
Timeframe: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on glucose
Timeframe: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)