Cardiotoxicity and Other Late Effects After Radiotherapy and Immuno-chemoTherapy in Non-Hodgkin lYmphoma

Inclusion Criteria (survivors): * 5-15 year survivors from the patient cohort with (mediastinal) large B-cell non-Hodgkin lymphoma (ICD-code 9679) or diffuse large B-cell non-Hodgkin lymphoma (ICD-code 9684), treated with R-CHOP: * 200 survivors treated between five to ten years ago (2007-2012) * 150 survivors treated between ten to fifteen years ago (2002-2007) * Treated in one of the following centers: AVL, Amsterdam UMC (location VUmc or AMC), LUMC, EMC, UMCU, UMCG, UMC Radboud. * Age at diagnosis 15 up to 60 years. * Age at the time of inclusion: younger than 75 years old. Exclusion criteria (survivors): * Use of immunosuppressant and/or prednisolone * HIV-infected individuals * Pregnant women * Mental disability or psychological condition potentially hampering compliance with the study protocol * Insufficient understanding of the Dutch language Inclusion criteria (siblings): 175 siblings of the above mentioned patients (maximum of 1 sibling per patient) with their date of birth closest to the birthdate of the survivor. Exclusion Criteria (siblings): * Use of immunosuppressant and/or prednisolone * HIV-infected individuals * Pregnant women * Mental disability or psychological condition potentially hampering compliance with the study protocol * Insufficient understanding of the Dutch language