Hyaluronic Acid for Prevention of Post-Intubation Sore Throat and Hoarseness (NCT07040631) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Hyaluronic Acid for Prevention of Post-Intubation Sore Throat and Hoarseness
92 participantsStarted 2025-06
Plain-language summary
The goal of this clinical trial is to find out whether applying Endotra Gel, a hyaluronic acid-based gel, to the endotracheal tube can help reduce sore throat and hoarseness after surgery.
These symptoms are common after general anesthesia when a endotracheal tube is placed into the trachea. They can cause discomfort and affect patient recovery.
The main questions this study aims to answer are:
* Does Endotra Gel reduce the chance of having a sore throat after surgery?
* Does it help improve hoarseness or coughing after surgery?
Participants in this study will:
* Undergo general anesthesia for breast cancer surgery
* Be randomly assigned to one of two groups:
* One group will receive Endotra Gel applied to the endotracheal tube before intubation
* The other group will have standard care with no gel
* Be monitored for sore throat, hoarseness, and coughing right after surgery and on the day after surgery
* Answer questions about their symptoms and satisfaction with their recovery The results will help researchers learn whether using Endotra Gel during intubation can improve patient comfort and reduce airway irritation after surgery.
Who can participate
Age range
19 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 19 to 80 years
* Scheduled to undergo breast cancer surgery under general anesthesia with endotracheal intubation
* American Society of Anesthesiologists (ASA) physical status I to III
Exclusion Criteria:
* Mallampati classification of III or higher
* Recent upper respiratory infection or symptoms of upper airway infection
* Pre-existing laryngeal disease or chronic respiratory conditions (e.g., asthma, chronic bronchitis)
* Current use of systemic steroids
* Refusal to provide informed consent
* Determined to be unsuitable for study participation by the investigator
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence and Severity of Postoperative Sore Throat