Testing the Effect of Sulforaphane, a Compound Naturally Found in Cruciferous Vegetables, on Preventing Melanoma in Patients With a Prior History of Melanoma

Inclusion Criteria: * Patient must have ≥ 3 clinically atypical nevi, assessed within 30 days prior to randomization, that are consistent with the International Agency for Research on Cancer (IARC) definition as follows.27 * Must have a diameter of ≥ 5mm in one dimension * Must include a macular component in at least one area * Must have at least two of the following features: ill-defined borders, color variegation, uneven contour, and erythema * Patient must have a prior diagnosis of early-stage melanoma, defined as either melanoma in situ, localized resected stage I-II node negative melanoma, or resected node positive stage III melanoma who in the assessment of their physician have a low risk of relapse of their prior melanoma within one year of randomization. * Patient must not be currently on targeted or checkpoint immunotherapy or treated within 365 days prior to randomization. * Patient must be ≥ 18 years of age. * Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible. * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial. * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral…