Efficacy and Safety of Egg Ladders in Children With IgE-Mediated Hen's Egg Protein Allergy

Inclusion Criteria: * Age ≥ 12 months and ≤ 5 years. * Diagnosis of IgE-mediated HEA confirmed according to the EAACI guidelines by a positive OFC with hen's egg proteins. In children with high-risk HEA (e.g., history of anaphylaxis), diagnosis can be based on elevated specific IgE levels (3.5 kU/l) to hen's egg proteins and/or individual egg components and/or positive skin tests. * On a therapeutic elimination diet for at least 6 months, measured from the last allergic reaction to egg (in accordance with BSACI guidelines). * Eligible regardless of the risk of systemic reactions (e.g. anaphylaxis) or asthma. * Good general health. * Written informed consent signed by the child's guardians. * Demonstrated good cooperation from the patient's guardians. Exclusion Criteria: * Confirmed wheat allergy and/or celiac disease. * Uncontrolled asthma, defined as the presence of shortness of breath, cough, chest tightness, or auscultatory changes despite treatment. * Signs of exacerbation of a chronic disease. * Signs of acute infectious disease (e.g. acute rhinitis, cough, subfebrile or febrile states). * Signs of exacerbation of another allergic disease (e.g., conjunctivitis, allergic rhinitis, atopic dermatitis). * Anaphylaxis due to hen's egg proteins within the last 6 months. * Use of antihistamines within 3-10 days before the challenge (depending on the drug and indication; time-limited contradiction - relative exclusion criterion). * Acquired tolerance to baked hen's egg protei…