RecruitingNot Applicable

Meaning in Music-Based Pain Modulation

United States50 participantsStarted 2025-10-25

Plain-language summary

The overall goal of this project is to examine the impact of music's meaning on pain. Relationships between trait affect, meaning in life, and subjective qualities of meaningful music will be assessed. We will also conduct interviews with a subset of participants to determine which aspects of music are most meaningful and how this meaning increases or decreases pain sensations.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18-65 years old * Absence of acute or chronic pain * Normal hearing (either naturally or with assistance of hearing device) * Must be able to wear an EEG * Able to sign consent Exclusion Criteria: * \< 18 or \> 65 years old * Presence of acute pain (brief pain inventory score \> 3) * Pregnant women * Participant reports that they experience pain on more days than not in the past 6 months (i.e., chronic

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Pain Unpleasantness

Timeframe: Baseline/Pre-intervention and During the Intervention

Pain Intensity

Timeframe: Baseline/Pre-intervention and During the Intervention

Trial details

NCT IDNCT07036315

SponsorUniversity of Virginia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-15

Contact for this trial

Claudia Denoue, MD

4342436744 TTC8WZ@uvahealth.org

View on ClinicalTrials.gov More The Focus of the Study is Healthy Volunteers trials