By InvitationPhase 4

Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients

Egypt60 participantsStarted 2025-04-01

Plain-language summary

This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy. Outcomes include extubation quality, vital signs, sedation, and adverse effects.

Who can participate

Age range30 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 30 and 60 years American Society of Anesthesiologists (ASA) physical status II Diagnosed hypertension Scheduled for elective craniotomy under general anesthesia Able and willing to provide informed consent Exclusion Criteria: * ASA physical status III or IV Uncontrolled comorbidities (e.g., diabetes mellitus) Coagulopathy or current use of anticoagulant or antiplatelet therapy Known allergy or hypersensitivity to dexmedetomidine or labetalol Emergency craniotomy Pregnant or breastfeeding women Patients with a history of severe cardiac arrhythmias Inability to provide informed consent

What they're measuring

Quality of Extubation Assessed Using a Standardized 5-Point Scale

Timeframe: Within the first 5 minutes after extubation

Trial details

NCT IDNCT07034898

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-31

View on ClinicalTrials.gov More Airway Stress Response trials