CompletedNot Applicable

Effect of Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin Levels on IVF Results in Male Factor Infertility

Turkey (Türkiye)122 participantsStarted 2023-04-01

Plain-language summary

Thiol-disulfide Homeostasis (TDH) is essential for physiological functions in the human reproductive system, including antioxidant defense, detoxification, signal transduction, enzymatic regulation, apoptosis, and cellular communication. Ischemia-Modified Albumin (IMA) serves as an indicator of oxidative stress (OS) and is linked to ischemia-reperfusion injury. This study aimed to investigate changes in OS markers, particularly TDH and IMA levels, in couples with male infertility, and to examine the relationship between these markers and in vitro fertilization (IVF) success. Understanding how TDH and IMA levels influence IVF outcomes is crucial for advancing reproductive treatments for couples having diagnosis of infertility.

Who can participate

Age range23 Years – 45 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Couples in which women aged 23-45 years and undergoing IVF treatment due to male factor and unexplained infertility were enrolled. \- Exclusion Criteria: Patients with hepatic or renal disease, systemic infections, systemic inflammatory disorders (such as diabetes mellitus, thyroid hormone disorders, rheumatologic, autoimmune, endocrine, neoplastic or other inflammatory conditions), or a diagnosis of endometriosis were excluded from the study. Smokers were excluded. Additionally, women with diminished ovarian reserve (DOR) were also not included in this study. \-

What they're measuring

Live birth rate (LBR)

Timeframe: 6 months

beta-human chorionic gonadotropin (hCG) positivity

Timeframe: 6 months

clinical pregnancy (CP)

Timeframe: 6 months

Trial details

NCT IDNCT07033429

SponsorDuzce University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-10-31

View on ClinicalTrials.gov More The Serum Native Thiol (NT) trials

Plain-language summary

Who can participate

Age range23 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.