Clinical Impact Through AI-assisted MS Care - A Prospective Multi-center Study

Inclusion Criteria: * Able to independently understand, evaluate and sign the informed consent form. * Able to comply with the study protocol, including having a mobile device capable of running the icompanion app. * Have a definite diagnosis of MS, confirmed as per revised McDonald 2017 criteria (treated or untreated) and/or a diagnosis of RIS/CIS (following the revised McDonald criteria presented during ECTRIMS 2024) * Patients early in the disease course of RRMS (CIS/RIS, RRMS with disease duration \< 7 years), patients with initial diagnosis of relapsing MS and disease duration 12-18 years (prone to convert to SPMS). * Clinical and brain MRI data available at least one year prior to the study * Age \>= 18 years Exclusion Criteria: * Unable or unwilling to understand, evaluate and sign the informed consent form. * Any contraindications for undergoing an MRI. * Currently involved in another interventional study. * Currently pregnant or planning a pregnancy in the coming 2 years. * Any concomitant disease that may require chronic treatment with systemic corticosteroids or immunosuppressants during the study. * Retrospective MRI not meeting requirements: at least, 3D T1-weighted images and fluid-attenuated inversion recovery (FLAIR) images (3D, or 2D with maximal slice thickness of 3mm). * Patients with confirmed diagnosis of PPMS.