CompletedNot Applicable

Intrauterine Growth Restriction and Intrauterine Fetal Death

Turkey (Türkiye)90 participantsStarted 2025-03-11

Plain-language summary

This study investigated whether delaying the clamping of the umbilical cord after birth can reduce harmful oxidative stress in newborns, especially in those who did not grow well during pregnancy (intrauterine growth restriction - IUGR). By comparing early and delayed cord clamping in 90 newborns, researchers found that delayed clamping improved antioxidant protection and reduced signs of oxidative damage. These benefits were more significant in babies with IUGR. The results suggest that delaying cord clamping could help support better early health outcomes in vulnerable newborns.

Who can participate

Age range0 Hours – 1 Hour

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Neonates born at ≥29 weeks of gestation * Diagnosed with Intrauterine Growth Restriction (IUGR) or classified as Appropriate for Gestational Age (AGA) based on prenatal ultrasonography * For IUGR group: estimated fetal weight below the 10th percentile and abnormal umbilical artery Doppler findings (e.g., elevated resistance index, absent or reversed end-diastolic flow) * Neonates delivered at Kayseri City Hospital * Informed consent obtained from parents or legal guardians Exclusion Criteria: * Major congenital anomalies or structural malformations * Intrauterine infections * Preterm birth before 29 weeks of gestation * Fetal hydrops * Maternal conditions such as preeclampsia, gestational diabetes, or systemic disease * Emergency cesarean delivery * Neonates requiring immediate postnatal intubation or invasive resuscitation * Signs of severe perinatal distress preventing umbilical cord sampling

What they're measuring

Total Antioxidant Status (TAS)

Timeframe: At birth (within 30 minutes postpartum)

Total Oxidant Status (TOS)

Timeframe: At birth (within 30 minutes postpartum)

Oxidative Stress Index (OSI)

Timeframe: At birth (within 30 minutes postpartum)

Trial details

NCT IDNCT07031583

SponsorIstanbul Arel University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-01

View on ClinicalTrials.gov More Intrauterine Growth Restriction (IUGR) trials

Plain-language summary

Who can participate

Age range0 Hours – 1 Hour

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.