CompletedNot Applicable

Effect of a Liquid Tonic Drink on Post-meal Glucose and Insulin Responses

Australia20 participantsStarted 2025-07-08

Plain-language summary

A randomised, double blinded, placebo-controlled crossover design clinical trial conducted at the Mary MacKillop Institute for Health Research (MMIHR, Australian Catholic University) for individuals with overweight/ obesity. This study will measure the postprandial glucose and hormone responses to a high-carbohydrate meal with/ without a liquid tonic drink.

Who can participate

Age range

30 Years – 64 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged ≥30-64 years * Body Mass Index (BMI) of ≥27.0 kg/m2 Exclusion Criteria: * younger than 30 or 65 years or older, * a BMI less than 27.0 kg/m2, * have an allergy to any of the components in the plant-based tonic (see section 6), * pregnant or breastfeeding, * regularly skipping breakfast (i.e. not consuming breakfast on 5/7 days per week), * any diagnosed metabolic (e.g. diabetes), endocrine (e.g. hyperthyroidism), gastrointestinal (e.g. Crohn's) or cardiovascular (e.g. heart failure) abnormalities, * on an energy-restricted diet; significant weight fluctuation in the previous 3 months (\>5% body weight), * high alcohol consumption (\>14 units/week) (as per Alcohol Drink Guidelines), * medication that is used to treat blood glucose, * unable to attend in person testing sessions, or * unable or unwilling to provide blood samples.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

3-hour postprandial glucose incremental area under the curve

Timeframe: 3 hours

Trial details

NCT IDNCT07030010

SponsorAustralian Catholic University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-19

View on ClinicalTrials.gov More Overweight or Obese Adults trials