Nutritional Oleic Acid Modulation of adIpose Cholesterol Metabolism in Patients Living With Obesity

Inclusion Criteria: * • Individual who has given informed consent. * Female adult aged between 18 and 60 years (included). * Patient with obesity at inclusion, meeting the HAS criteria for bariatric surgery eligibility: BMI ≥ 35 kg/m² associated with a comorbidity or BMI \> 40 kg/m². * European origin: For this pilot study, we need to reduce variability factors and focus the research on women of European descent only (having both parents identified by the patient as of European origin). * Effective contraception if sexually active, or abstinence, or menopause (criterion required for bariatric surgery). * Presenting at inclusion with at least two clinical criteria of insulin resistance according to the definition of the International Diabetes Federation (IDF): * Dysglycemia (fasting glucose ≥ 100 mg/dL, glucose intolerance, or type 2 diabetes). * Hypertension (≥ 130/85 mm Hg). * Low HDL-cholesterol (\< 50 mg/dL). * Elevated triglycerides (≥ 150 mg/dL). * Affiliated with a social security system or a beneficiary of such a system. * Bariatric surgery performed at Nantes University Hospital (CHU de Nantes). Exclusion Criteria: * • Modification of diabetes treatment within the past month. * Ongoing or planned insulin therapy before bariatric surgery. * Modification of lipid-lowering treatment within the past three months. * Systemic corticosteroid therapy. * Antiviral therapy (HIV). * Dietary supplementation affecting lipid metabolism,…