Emerging evidence suggests that concussions (a type of mild traumatic brain injury; mTBIs) may cause chronic neurological disturbances with effects lasting beyond 20 years, changing brain structure and nearly doubling the risks of developing dementia into old age. Yet diagnoses remain notoriously difficult, gender differences are poorly understood, and negligible therapies exist to manage and treat these long-term effects. This project proposes using a combination of NeuroTracker (a promising software-based cognitive assessment and intervention for mild TBIs), with the latest MRI techniques and blood-based biomarkers of brain function, to provide unprecedented assessment sensitivity of long-term concussion effects, comparing older male and female adults, with and without a history of concussion. Additionally, NeuroTracker will be used as a therapeutic intervention to improve outcomes in adults with histories of concussion, with the combined assessments measuring efficacy pre-post training. This project aims to comprehensively understand the impacts of mild brain traumas into later life, via both physical and functional biomarkers of brain health. It will also validate the value of NeuroTracker as an accessible training intervention for recovering cognitive functions impacted by earlier-life concussions.
Age range
60 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Neuropsychological cognitive assessments
Timeframe: By the end of the second year.
Neuropsychological cognitive assessments
Timeframe: By the end of the second year.
Neuropsychological cognitive assessments
Timeframe: By the end of the second year.
Neuropsychological cognitive assessments
Timeframe: By the end of the second year.
Neuropsychological cognitive assessments
Timeframe: By the end of the second year.
Neuropsychological cognitive assessments
Timeframe: By the end of the second year.
Multimodal biomarker assessment
Timeframe: By the end of the second year
Eduardo Lugo Project Manager, PhD
Multimodal biomarker assessment
Timeframe: By the end of the second year
Multimodal biomarker assessment
Timeframe: By the end of the second year
Multimodal biomarker assessment
Timeframe: By the end of the second year
NeutroTracker assessement
Timeframe: By the end of the second year