A Safety and Tolerability Clinical Trial of PST-611 in Dry Age-related Macular Degeneration

Inclusion Criteria: * must give written informed consent, be able to make the required trial visits and follow instructions. * Female and male subjects 50 years of age or older. * Female subjects of childbearing potential must not be pregnant or breast-feeding and must have a negative urine pregnancy test at baseline and throughout the study. They must agree to practice at least one effective method of birth control following administration of study medication. * In the study eye (SE) : at least one of the following must be present at OCT and attributed to AMD, as evaluated by the Investigator: Incomplete RPE and Outer Retinal Atrophy (iRORA), or Complete RPE and Outer Retinal Atrophy (cRORA). * In SE: BCVA must be 23 ETDRS letters (approximate Snellen equivalent 20/320) or better. * In the fellow eye: BCVA must be 34 letters (approximate Snellen equivalent 20/200) or better. Exclusion Criteria: \- Both eyes: any active intraocular or periocular infection or inflammation (eg, infectious blepharitis, infectious conjunctivitis, keratitis, scleritis, endophthalmitis), or history of intraocular or periocular infection or inflammation in the 12 weeks (84 days) prior to the PST-611 administration. Study eye: Any intraocular surgery (including cataract surgery) or intravitreal (IVT) or periocular corticosteroid injection within 12 weeks (84 days) prior to the PST-611 administration. * SE: Any anti-VEGF IVT treatment within 4 weeks (28 days) prior to PST-611 dosing OR subjects w…