WithdrawnPhase 2

Genicular Embolization Using Doxycycline Sclerotherapy

Stopped: unable to obtain IND approval from FDA

0Started 2026-06

Plain-language summary

The goal of this prospective case series is to develop an alternative pain management procedure for patients who are not surgical candidates. The main question it aims to answer is: Is genicular sclerotherapy using doxycycline a safe and effective pain management option for patients with chronic knee pain who are not surgical candidates? OUTCOME MEASURES: Primary: Visual Analog Scale (VAS) score at 3 months Secondary: * VAS at 12 months * Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at 12 months

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least 18 years of age or older. * KL Score 2-3 * VA Grade \>5 * Native knee * Willing and able to provide consent. * Willing and able to complete questionnaires. * Willing and able to complete follow up visits. * Speak and write fluent English * Unilateral knee (if bilateral knee pain, identify knee for procedure) * All subjects may be included regardless of sex. Women must be either surgically sterilized postmenopausal defined as having no menstrual periods for 12 consecutive months Exclusion Criteria: * Allergies to doxycycline or any other substances used in procedure * Steroid injection in the index knee within the last 90 days * Knee surgery on index knee in the last 180 days

What they're measuring

Visual Analog Scale (VAS)

Timeframe: 3 months post-op

Trial details

NCT IDNCT07024654

SponsorCampbell Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-06

View on ClinicalTrials.gov More Chronic Knee Pain trials