WithdrawnPhase 2

Genicular Embolization Using Doxycycline Sclerotherapy

Stopped: unable to obtain IND approval from FDA

0Started 2026-06

Plain-language summary

The goal of this prospective case series is to develop an alternative pain management procedure for patients who are not surgical candidates. The main question it aims to answer is: Is genicular sclerotherapy using doxycycline a safe and effective pain management option for patients with chronic knee pain who are not surgical candidates? OUTCOME MEASURES: Primary: Visual Analog Scale (VAS) score at 3 months Secondary: * VAS at 12 months * Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at 12 months

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least 18 years of age or older. * KL Score 2-3 * VA Grade \>5 * Native knee * Willing and able to provide consent. * Willing and able to complete questionnaires. * Willing and able to complete follow up visits. * Speak and write fluent English * Unilateral knee (if bilateral knee pain, identify knee for procedure) * All subjects may be included regardless of sex. Women must be either surgically sterilized postmenopausal defined as having no menstrual periods for 12 consecutive months Exclusion Criteria: * Allergies to doxycycline or any other substances used in procedure * Steroid injection in the index knee within the last 90 days * Knee surgery on index knee in the last 180 days

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Visual Analog Scale (VAS)

Timeframe: 3 months post-op

Trial details

NCT IDNCT07024654

SponsorCampbell Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-06

View on ClinicalTrials.gov More Chronic Knee Pain trials