Hemodynamics After Resistance Training (NCT07022340) | Clinical Trial Compass
RecruitingNot Applicable
Hemodynamics After Resistance Training
United States50 participantsStarted 2025-06-06
Plain-language summary
Women's blood vessel health gets worse after menopause, or "the change of life". Some women exercise less during menopause. Exercise can improve blood vessel health. The investigators want to know if resistance exercise, like lifting weights, can improve blood vessel health in women who are just starting menopause. The investigators also want to know if lifting weights can improve mood, sleep, and quality of life in women going through menopause. The investigators will have two groups of women for this study. One group will lift weights (do resistance exercise) twice per week, and the other group will get emails with information about menopause. The investigators will measure blood vessel health, sleep, mood, and menopause symptoms at the start and the end of this study and compare women who did and did not exercise.
Who can participate
Age range
40 Years – 60 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* Are between 40-60 years old
* Have had menstrual irregularities in the last 12 months
* Do not currently complete more than two 30-min sessions of structured exercise per week and do not do any resistance training exercise;
* Are not currently pregnant
* Do not smoke or vape nicotine or marijuana
* Have not had an oophorectomy, hysterectomy, or surgical menopause
* Are not currently taking hormone replacement therapy
* Have not taken hormone replacement therapy in the last 6 months
* Are not taking steroidal medication or medication to treat diabetes, cholesterol, or high blood pressure
* Are able to exercise - your doctor has not told you that you cannot exercise
* Can attend a morning study visit at the University of Michigan's School of Kinesiology Building
* Are willing to avoid food 2 hours prior to the morning study visit
* Are willing to avoid strenuous exercise, caffeine, and alcohol, 8 hours prior to the morning study visit
* Are willing to participate in an exercise training program or health education program for 16 weeks
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is specifically studying women in perimenopause — how would my doctor determine whether I'm actually at that stage of hormonal transition and whether I'd be a good candidate to discuss with the research team?
2Since this is a study on resistance training and its effects on vascular and endothelial function, what do those measurements actually mean for my heart and blood vessel health, and why might they matter during perimenopause specifically?
3The trial is listed as 'Phase NA,' which suggests it may be a behavioral or exercise intervention rather than a drug trial — does that change the risk profile compared to a typical medication study, and what physical demands or exercise requirements should I ask the research team about before considering it?
4Would participating in a resistance training study like this interfere with any current treatments or medications I'm on, or with other lifestyle changes my doctor has already recommended for my perimenopausal symptoms?
5If my doctor thinks this trial might not be the right fit for me right now, are there established standard-of-care options for protecting my cardiovascular health during perimenopause that I should be prioritizing instead?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Vascular function
Timeframe: At baseline and the end of the 16 week study period
2
Endothelial Function
Timeframe: At baseline and the end of the 16 week study period